PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis |
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Authors: | Cláudia M Vicente Javier Santos-Aberturas Susana M Guerra Tamara D Payero Juan F Martín and Jesús F Aparicio |
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Institution: | (1) Instituto de Biotecnolog?a INBIOTEC, 24006 Le?n, Spain;(2) Area de Microbiolog?a, Facultad de Biolog?a, Universidad de Le?n, 24071 Le?n, Spain |
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Abstract: | Background Polyenes represent a major class of antifungal agents characterised by the presence of a series of conjugated double bonds
in their planar hydroxylated macrolide ring structure. Despite their general interest, very little is known about the factors
that modulate their biosynthesis. Among these factors, we have recently discovered a new inducing compound (PI-factor) in
the pimaricin producer Streptomyces natalensis, which elicits polyene production in a manner characteristic of quorum sensing. Here, we describe the involvement of an amino-acid
exporter from S. natalensis in modulating the expression of pimaricin biosynthetic genes via secretion of the quorum-sensing pimaricin-inducer PI-factor. |
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