Vascular endothelial growth factor in malignant pleural effusion associated with lung cancer |
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Authors: | Hiroaki Yanagawa Eiji Takeuchi Yoshihiro Suzuki Yasukazu Ohmoto Hiroyasu Bando Saburo Sone |
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Institution: | (1) Third Department of Internal Medicine, The University of Tokushima School of Medicine, Kuramoto-cho 3 Tokushima, 770-8503 Japan e-mail: niseko@medclin.clin.med.tokushima-u.ac.jp Tel.: +81-88-633-7127 Fax: +81-88-633-2134, JP;(2) Department of Respiratory Diseases, Tokushima Prefectural Central Hospital, 10-3 Kuramoto-cho 1 Tokushima, 770-0042 Japan, JP |
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Abstract: | The presence of vascular endothelial growth factor (VEGF) was examined by enzyme immunoassay in 60 cytology-documented malignant
pleural effusions associated with primary lung cancer and 51 other benign and malignant pleural effusions. Exudative pleural
effusions contained significantly higher amounts of VEGF than transudative pleural effusions. Among exudative pleural effusions,
levels of VEGF in malignant pleural effusions associated with lung cancer were significantly higher than those of benign exudative
pleural effusions. There was no significant difference in pleural VEGF in patients with different histological types or clinical
stages of lung cancer. Serial measurement of pleural VEGF levels was performed in six lung cancer patients treated with intrapleural
instillation of recombinant interferon γ, and reduction of pleural effusion was associated with decreasing pleural VEGF levels.
These findings suggest that VEGF has a role in the accumulation of exudative pleural effusions, especially that of malignant
pleural effusion associated with lung cancer.
Received: 14 April 1999 / Accepted: 10 June 1999 |
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Keywords: | VEGF Exudative pleural effusion Malignant pleurisy Lung cancer Interferon γ |
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