Progress toward the development of a bacterial vaccine vector that induces high-titer long-lived broadly neutralizing antibodies against HIV-1 |
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Authors: | Fouts T R DeVico A L Onyabe D Y Shata M T Bagley K C Lewis G K Hone D M |
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Institution: | Division of Vaccine Research, Institute of Human Virology, 725 W. Lombard Street, Baltimore, MD 21201, USA. |
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Abstract: | Conformationally constrained HIV-1 Env and gp120 immunogens induce broadly cross-reactive neutralizing antibodies. Thus, it is now feasible to rationally design an HIV-1 vaccine that affords protection through humoral mechanisms. This paper reviews our progress toward the development of an oral bacterial vaccine vector that is capable of delivering an HIV-1 DNA vaccine to host lymphoid tissues and inducing broadly neutralizing antibodies to HIV-1 in the mucosal and systemic immune compartments. |
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Keywords: | Immunodeficiency virus Shigella Vaccine vector Mucosal immunity Salmonella |
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