Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives |
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| Authors: | Provins Laurent Christophe Bernard Danhaive Pierre Dulieu Jacques Gillard Michel Quéré Luc Stebbins Karin |
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| Affiliation: | UCB Pharma S.A., R&D, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium. laurent.provins@ucb-group.com |
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| Abstract: | Introduction of 3-substituted azetidinyl substituents onto the 4,6-diaminopyrimidine scaffold allowed the improvement of PDE4 inhibiting activities. Preliminary in vivo activity in pulmonary inflammation models is reported. |
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