Polyamines in inflammation and their modulation by conventional anti-inflammatory drugs |
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Authors: | Chakradhar Lagishetty V Naik Suresh Ramnath |
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Institution: | Department of Pharmacology and Toxicology, Prin. K.M.Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai 400 005, India. |
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Abstract: | Significant increase in polyamines levels in inflamed tissue was observed in the experimental animal models of inflammation. Treatment with dexamethasone positively modulated the levels of polyamines whereas non-steroidal drugs, diclofenac and valdecoxib negatively modulated their levels. |
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