Both R5 and X4 human immunodeficiency virus type 1 variants persist during prolonged therapy with five antiretroviral drugs |
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| Authors: | van Rij Ronald P Visser Janny A van Praag Rieneke M E Rientsma Ronald Prins Jan M Lange Joep M A Schuitemaker Hanneke |
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| Institution: | Department of Clinical Viro-Immunology, CLB/Sanquin and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands. |
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| Abstract: | A viral reservoir of human immunodeficiency virus type 1 (HIV-1)-infected, resting CD4(+) T cells persists despite suppression of plasma viremia by combination antiretroviral therapy. In a longitudinal analysis of three patients treated with a five-drug regimen, both R5 and X4 HIV-1 variants persisted in the cellular reservoir for up to 3 years. |
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