Fatty acid amide hydrolase substrate specificity |
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| Authors: | Boger D L Fecik R A Patterson J E Miyauchi H Patricelli M P Cravatt B F |
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| Affiliation: | Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. boger@scripps.edu |
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| Abstract: | Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. |
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