Platinum(II) complexes of 4-methoxy- and 4-chlorobenzoic acid hydrazides. Synthesis, characterization, and cytotoxic effect |
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| Authors: | Nicolay Dodoff Konstantin Grancharov Nadejda Spassovska |
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| Institution: | Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria |
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| Abstract: | The complexes Pt(NH3)(pmbah)Cl2], Pt(NH3)(pcbah)Cl2], Pt(pmbah2X2] and Pt(pcbah)2X2] (pmbah = 4-methoxybenzoicacid hydrazide, pcbah = 4-chlorobenzoic acid hydrazide; X = Cl, Br, I) have been synthesized and characterized by elemental analysis, electric conductivity, 1H NMR, IR, and electronic spectra. A cis-square planar structure with hydrazide ligands coordinated via the NH2 groups has been proposed for these compounds. The complexes, but not the free ligands, have shown a strong growth inhibitory effect in Friend leukemia cells in vitro, most of which are more active than cisplatin. |
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