Mutagenicity of BCNU and related chloroethylnitrosoureas in Drosophila. |
| |
Authors: | M J Kortselius |
| |
Institution: | Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, State University of Leiden, Wassenaarseweg 72, Leiden The Netherlands |
| |
Abstract: | BCNU and 10 related chloroethylnitrosoureas were tested for their ability to induce sex-linked recessive lethals in Drosophila spermatozoa. All chloroethylnitrosoureas tested were potent mutagens. Among the substances with one chloroethylnitrosourea group, chlorozotocin, BCNU and methanesulfonyloxyethyl chloroethylnitrosourea exhibited the strongest mutagenic effects. Two hydroxyalkyl chloroethylnitrosoureas behaved as potent mutagens too, although the mutation frequencies obtained were one order of magnitude lower relative to the other substances. Among the compounds with two chloroethylnitrosourea groups, bisCNU-ethane and bisCNU-diphenylmethane were most active. When the interconnecting polymethylene chain was elongated from 2 methylene groups (bisCNU-ethane) to 6 methylene groups (bisCNU-hexane), the mutagenic activity decreased by a factor of 2. The mutagenic activity of polymethylene bischloroethylnitrosoureas with connecting chains of intermediate length was not different from bisCNU-hexane. Differences in mutagenic activity were supposed to reflect different concentrations reaching the target cells, possibly in part as a result of differences in transportability of the substances. |
| |
Keywords: | BCNU 1 3-bis(2-chloroethyl)-1-nitrosourea bisCNU-diphenylmethane 1 1′-diphenylmethylene bis-3-(2-chloroethyl)-3-nitrosourea bisCNU-ethane to bisCNU-hexane 1 1′-polymethylenebis-3-(2-chloroethyl)-3-nitrosoureas chlorozotocin 1-(glucopyranos-2-yl)-3-(2-chloroethyl)-3-nitrosourea CNU-ethanol 1-(ω-hydroxyalkyl)-3-(2-chloroethyl)-3-nitrosoureas CNU-propanol 1-(ω-hydroxyalkyl)-3-(2-chloroethyl)-3-nitrosoureas ENU 1-ethyl-1-nitrosourea MNU 1-methyl-1-nitrosourea MSO-CNU 1-(2-methane-sulfonyloxyethyl)-3-(2-chloroethyl)-3-nitrosourea |
本文献已被 ScienceDirect 等数据库收录! |
|