Quantitative determination of astilbin in rabbit plasma by liquid chromatography |
| |
Authors: | Guo Jianming Xu Qiang Chen Ting |
| |
Institution: | School of Life Sciences, Nanjing University, Nanjing 210093, China. |
| |
Abstract: | A simple method for determining the concentration of astilbin, a flavanone, in rabbit plasma has been developed. After liquid-liquid extraction, the flavanone was detected by HPLC on a 4.6-microm octadecylsilica column (Nova-Pak C-18) at 291 nm. Linear calibration graphs for astilbin were constructed from 0.44 to 22.17 microM. The limit of quantitation was 0.44 microM in plasma. The method has been applied to pharmacokinetic studies after a single i.v. and an oral administration of the compound to rabbits. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|