Localization of substance P and leucine enkephalin in the nerve terminals of the guinea pig paracervical ganglion |
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Authors: | B. S. Mitchell and V. V. Stauber |
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Affiliation: | (1) Human Morphology, Faculty of Medicine, University of Southampton, Biomedical Sciences Building, SO9 3TU Southampton, UK |
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Abstract: | Summary Immunoreactivities (IR) of substance P and leucine enkephalin have been demonstrated in the guinea-pig paracervical ganglion by an immunogold electron microscope method. Both substance P-IR and leucine enkephalin-IR were detected in large synaptic vesicles with electron-dense cores. The former neuropeptide was detected in nerve terminals and varicosities comprised mainly of large vesicles with electron-dense cores; the latter was detected in nerve terminals and varicosities that also included small, clear synaptic vesicles. In a minority of nerve terminals and varicosities coexistence of both immunoreactivities could be demonstrated within vesicles with an electron-dense core. Also present in these nerve terminals and varicosities were small, clear synaptic vesicles, though these were unreactive. |
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