Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation |
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| Authors: | Don Hayward Paul D van Helden Ian JF Wiid |
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| Affiliation: | (1) DST/NRF Centre for Excellence in Biomedical Tuberculosis Research, US/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences –, Stellenbosch University, PO Box 19063, Francie van Zijl Drive, TYGERBERG, 7505, South Africa |
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| Abstract: | Background Although the gene encoding for glutamine synthetase (gln A) is essential in several organisms, multiple glnA copies have been identified in bacterial genomes such as those of the phylum Actinobacteria, notably the mycobacterial species. Intriguingly, previous reports have shown that only one copy (gln A1) is essential for growth in M. tuberculosis, while the other copies (gln A2, gln A3 and gln A4) are not. |
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