The effects of ruthenium tetraammine compounds on vascular smooth muscle. |
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| Authors: | P G Zanichelli H F G Estrela R C Spadari-Bratfisch D M Grassi-Kassisse D W Franco |
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| Affiliation: | 1. Departamento de Química Inorgânica, Instituto de Química de São Carlos, Universidade de São Paulo (USP), São Carlos, SP, Brazil;2. Laboratório de Estudo de Estresse, Depto de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil;3. Departamento de Ciências da Saúde, Universidade Federal de São Paulo, Santos, São Paulo, Brazil |
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| Abstract: | The time course of the relaxation effect induced by a single dose (3 x 10(-6) mol/L) of trans-[Ru(NH3)4L(NO)]3+ (L=nic, 4-pic, py, imN, P(OEt)3, SO(3)(2-), NH3, and pz) species and sodium nitroprusside (4 x 10(-9) mol/L) was studied in aortic rings without endothelium and pre-contracted with noradrenaline (1 x 10(-6) mol/L). All the compounds induced a relaxing effect in the aortic rings, but the intensity and time of relaxation were different. Only the species where L=py, 4-pic, and P(OEt)3 were able to induce 100% (99-100%) of the relaxing effect during the assay. trans-[Ru(NH3)4(L)(NO)]3+ (L=SO(3)(2-) and NH3) showed the lowest relaxing effect (36 and 37%, respectively) when compared with the other compounds. Relationship was observed between the time corresponding to half of the maximum relaxation intensity observed and, respectively, k-NO, E0'[Ru(NO)]3+/[Ru(NO)]2+ in trans-[Ru(NH3)4(L)(NO)]3+ species and E0'Ru(III)/Ru(II) in trans-[Ru(NH3)4(L)(H2O)]3+ ions. These relationships strongly suggested that the NO liberation from the reduced nitrosyl complexes was responsible for the observed relaxation. |
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