Oral supplementation with carbohydrate- and branched-chain amino acid-enriched nutrients improves postoperative quality of life in patients undergoing hepatic resection |
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Authors: | Takehiro Okabayashi Miho Iyoki Takeki Sugimoto Michiya Kobayashi Kazuhiro Hanazaki |
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Institution: | (1) Department of Surgery, Kochi Medical School, Kohasu-Okocho, Nankoku, Kochi 783-8505, Japan;(2) Nutrition Support Team at Kochi Medical School, Kochi, Japan |
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Abstract: | The long-term outcomes of branched-chain amino acid (BCAA) administration in patients undergoing hepatic resection remain
unclear. The aim of this study is to assess the impact of oral supplementation with BCAA-enriched nutrients on postoperative
quality of life (QOL) in patients undergoing liver resection. A prospective randomized clinical trial was conducted in 96
patients undergoing hepatic resection. Patients were randomly assigned to receive BCAA supplementation (AEN group, n = 48) or a conventional diet (control group, n = 48). Postoperative QOL and short-term outcomes were regularly and continuously evaluated in all patients using a short-form
36 (SF-36) health questionnaire and by measuring various clinical parameters. This study demonstrated a significant improvement
in QOL after hepatectomy for liver neoplasm in the AEN group based on the same patients’ preoperative SF-36 scores (P < 0.05). Perioperative BCAA supplementation preserved liver function and general patient health in the short term for AEN
group patients compared to those not receiving the nutritional supplement. BCAA supplementation improved postoperative QOL
after hepatic resection over the long term by restoring and maintaining nutritional status and whole-body kinetics. This study
was registered at (registration number: NCT00945568). |
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