HMB supplementation: clinical and athletic performance-related effects and mechanisms of action |
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Authors: | Nelo Eidy Zanchi Frederico Gerlinger-Romero Lucas Guimarães-Ferreira Mário Alves de Siqueira Filho Vitor Felitti Fabio Santos Lira Marília Seelaender Jr" target="_blank">Antonio Herbert LanchaJr |
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Institution: | 1.Laboratory of Applied Nutrition and Metabolism, Physical Education and Sports School,University of Sao Paulo,S?o Paulo,Brazil;2.Department of Physiology and Biophysics, Institute of Biomedical Sciences,University of Sao Paulo,S?o Paulo,Brazil;3.Division of Nutrition Physiology, Department of Physiology,Federal University of Sao Paulo,S?o Paulo,Brazil;4.Cancer Metabolism Research Group, Department of Cell and Developmental Biology, Institute of Biomedical Sciences,University of Sao Paulo,S?o Paulo,Brazil;5.Department of Sports, Center of Physical Education and Sports,Federal University of Espirito Santo,Vitória/ES,Brazil |
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Abstract: | Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be the focus of studies, mainly because
of their anti-catabolic properties, through inhibition of muscle proteolysis and enhancement of protein synthesis. It is clear
that these effects may counteract catabolic conditions, as well as enhance skeletal muscle mass and strength in athletes.
Moreover, beta-hydroxy-beta-methylbutyrate (HMB) has been shown to produce an important effect in reducing muscle damage induced
by mechanical stimuli of skeletal muscle. This review aims to describe the general scientific evidence of KIC and HMB supplementation
clinical relevance, as well as their effects (e.g., increases in skeletal muscle mass and/or strength), associated with resistance
training or other sports. Moreover, the possible mechanisms of cell signaling regulation leading to increases and/or sparing
(during catabolic conditions) of skeletal muscle mass are discussed in detail based on the recent literature. |
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