| A-超家族芋螺毒素研究进展 |
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| 引用本文： | 陈伟华,王志强,韩禹宏. A-超家族芋螺毒素研究进展[J]. 生命科学, 2006, 18(4): 373-379 |
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| 作者姓名： | 陈伟华 王志强 韩禹宏 |
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| 作者单位： | 华东理工大学生物工程学院,上海,200237;同济大学蛋白质研究所,上海,200092;同济大学蛋白质研究所,上海,200092;同济大学蛋白质研究所,上海,200092;中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海,200031 |
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| 基金项目： | 国家自然科学基金(30471930) |
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| 摘 要： | 芋螺毒素是生物毒素中迅速发展的新领域,是很有价值的药物或药物先导化合物,其中A-超家族芋螺毒素是研究最早、了解较为全面的芋螺毒素家族之一,由于其高丰度、化学多样性、强专一性作用等突出特点成为创新药物发展的宝库。A-超家族芋螺毒素因能选择性阻断nAChRs的某种亚型,使它们可作为鉴定nAChRs及其亚基的有效工具。此外,在药理学方面,A-超家族芋螺毒素除了作为镇痛药物已进入临床研究外,也有望开发成用于治疗焦虑症、帕金森氏病、肌肉紧张和高血压等病症的药物。
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| 关 键 词： | 芋螺毒素 超家族 离子通道 二硫键 |
| 文章编号： | 1004-0374（2006）04-0373-07 |
| 收稿时间： | 2005-11-21 |
| 修稿时间： | 2006-03-31 |
The progress in studies on A-superfamily conotoxins |
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| CHEN Wei-Hua,WANG Zhi-Qiang,HAN Yu-Hong. The progress in studies on A-superfamily conotoxins[J]. Chinese Bulletin of Life Sciences, 2006, 18(4): 373-379 |
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| Authors: | CHEN Wei-Hua WANG Zhi-Qiang HAN Yu-Hong |
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| Affiliation: | 1Bioengineering Institute, East China University of Science and Technology, Shanghai 200237, China; 2 Institute of Protein Research, Tongji University, Shanghai 200092, China; 3 Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China |
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| Abstract: | Conotoxin is a new area that attracts increasing attention and developes rapidly in biological toxins.They are valuable polypeptides that can be used as medicine or its precursor.Among them,the A-superfamilyCTx are the earliest studied.Due to their abundance,chemical diversity,high-specific effect and other advantages,they have become a precious treasure for developing new medicines.A-superfamily CTx have a selective blockingeffect on different subtype of nAChRs,so they are effective tools to identify different subtype or subunit ofnAChRs.Additionally in pharmacology,A-superfamily CTx are not only studied in clinical phase as medicine toease pains,but also very possible to be developed to treat anxiety disorder,parkinsonism,muscular tension,hypertension and other diseases. |
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| Keywords: | conotoxins superfamily ion channel disulfide bond |
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