Target cells for 1,25 dihydroxyvitamin D3 in the pancreas |
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| Authors: | Samuel A Clark Dr Walter E Stumpf Madhabananda Sar Hector F DeLuca Yoko Tanaka |
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| Institution: | (1) Department of Anatomy, University of North Carolina, 111 Swing Building, 27514 Chapel Hill, N.C., USA;(2) Department of Biochemistry, University of Wisconsin, 53706 Madison, WI, USA |
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| Abstract: | Summary Mature rats raised on a vitamin D deficient diet were injected with tritium labeled 1,25 dihydroxyvitamin D3. Concentration of radioactivity, which is prevented by pretreatment with unlabeled 1,25 dihydroxyvitamin D3, is found in nuclei of cells that are centrally located in pancreatic islets. The central location of these cells and supportive evidence from the literature suggest that they are B-cells, and that 1,25 dihydroxyvitamin D3 has a direct and genomic action on B-cell functions including insulin secretion.Supported by US Public Health Service Grants NS 09914 and AM 14881 |
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| Keywords: | B-cells 1 25 dihydroxyvitamin D3 Autoradiography Pancreaticislets |
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