Isolation of an Escherichia coli K4 kfoC mutant over-producing capsular chondroitin |
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| Authors: | Anna Zanfardino Odile F Restaino Eugenio Notomista Donatella Cimini Chiara Schiraldi Mario De Rosa Maurilio De Felice Mario Varcamonti |
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| Affiliation: | (1) Department of Structural and Functional Biology, University of Naples Federico II, Naples, Italy;(2) Department of Experimental Medicine, Second University of Naples, Italy |
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| Abstract: | Background Chondroitin sulphate is a complex polysaccharide having important structural and protective functions in animal tissues. Extracted from animals, this compound is used as a human anti-inflammatory drug. Among bacteria, Escherichia coli K4 produces a capsule containing a non-sulphate chondroitin and its development may provide an efficient and cheap fermentative production of the polysaccharide. |
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