Sub-chronic lung inflammation after airway exposures to <Emphasis Type="Italic">Bacillus thuringiensis</Emphasis> biopesticides in mice |
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| Authors: | Kenneth K Barfod Steen S Poulsen Maria Hammer Søren T Larsen |
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| Institution: | (1) National Research Centre for the Working Environment, Copenhagen, Denmark;(2) Statens Serum Institut, Copenhagen, Denmark;(3) Department of Biomedical Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark |
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| Abstract: | Background The aim of the present study was to assess possible health effects of airway exposures to Bacillus thuringiensis (Bt) based biopesticides in mice. Endpoints were lung inflammation evaluated by presence of inflammatory cells in bronchoalveolar
lavage fluid (BALF), clearance of bacteria from the lung lumen and histological alterations of the lungs. Hazard identifications
of the biopesticides were carried out using intratracheal (i.t.) instillation, followed by an inhalation study. The two commercial
biopesticides used were based on the Bt. subspecies kurstaki and israelensis, respectively. Groups of BALB/c mice were i.t instilled with one bolus (3.5 × 105 or 3.4 × 106 colony forming units (CFU) per mouse) of either biopesticide. Control mice were instilled with sterile water. BALFs were
collected and the inflammatory cells were counted and differentiated. The BALFs were also subjected to CFU counts. |
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