Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate |
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| Authors: | K Basler E Hafen |
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| Institution: | 1. Clinical Image Processing Service, National Institutes of Health Clinical Center, Bethesda, Maryland;2. Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr., Building 10, Rm. 1C224D MSC 1182, Bethesda, MD 20892-1182 |
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| Abstract: | Determination of cell fate in the compound eye of Drosophila appears to be controlled by cell-cell interactions. The sevenless gene plays an essential role in the determination of a single photoreceptor cell type (R7). It encodes a transmembrane protein with a cytoplasmic tyrosine kinase domain, as found in some growth factor receptors and the protein products of certain oncogenes. This might suggest that developmental decisions dependent on direct cellular interactions involve signalling mechanisms similar to those induced by diffusible factors such as hormones and growth factors. |
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