Monitoring Biophysical Properties of Lipid Membranes by Environment-Sensitive Fluorescent Probes |
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Authors: | Alexander P Demchenko Guy Duportail |
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Institution: | † Palladin Institute of Biochemistry, Kyiv, Ukraine ‡ Laboratoire de Biophotonique et Pharmacologie, Unité Mixte de Recherche 7213 Centre National de la Recherche Scientifique, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France |
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Abstract: | We review the main trends in the development of fluorescence probes to obtain information about the structure, dynamics, and interactions in biomembranes. These probes are efficient for studying the microscopic analogs of viscosity, polarity, and hydration, as well as the molecular order, environment relaxation, and electrostatic potentials at the sites of their location. Progress is being made in increasing the information content and spatial resolution of the probe responses. Multichannel environment-sensitive probes that can distinguish between different membrane physicochemical properties through multiple spectroscopic parameters show considerable promise. |
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