On the Paucity of Duplicated Genes in Caenorhabditis elegans Operons |
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| Authors: | Andre RO Cavalcanti Nicholas A Stover Laura F Landweber |
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| Institution: | (1) Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA;(2) Department of Biology, Pomona College, Seaver West, 175 West 6th Street, Claremont, CA 91711, USA;(3) Present address: Department of Genetics, Stanford University School of Medicine Stanford, CA 94305, USA |
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| Abstract: | Spliced leader trans-splicing is an mRNA maturation process used by a small set of eukaryotes, including the nematode C. elegans, to cap the downstream genes of operons. We analyzed the frequency of duplication of operonic genes in C. elegans and confirmed that they are duplicated less often in the genome than monocistronic genes. Because operons account for about
15% of the genes in C. elegans, this lower duplication frequency might place a large constraint on the plasticity of the genome. Further analyses suggest
that this paucity of duplicated genes results from operon organization hindering specific types of gene duplication.
Reviewing Editor: Dr. Yves van de Peer] |
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| Keywords: | Eukaryotic operon Trans-splicing Spliced leader Gene duplication |
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