Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques |
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| Authors: | Wim Van Hul Hubert Backhovens Guy Van Camp Piet Stinissen Marc Cruts Anita Wehnert Christine Van Broeckhoven |
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| Affiliation: | (1) Neurogenetics, Department of Biochemistry, Born-Bunge Foundation, University of Antwerp (UIA), B-2610 Antwerpen, Belgium;(2) Innogenetics Inc., Industriepark Zwijnaarde, B-9710 Gent, Belgium |
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| Abstract: | Summary We were able to refine the chromosomal position of two existing marker loci, using an extended chromosome 21 somatic cell hybrid panel. The locus D21S26 mapped in the region 21q11.2–q21.1, and the locus D21S24 in 21q22.1–q22.2. Physical and genetic analysis indicated that D21S26 is tightly linked to D21S13 and D21S16, two markers previously linked to familial Alzheimer's disease. |
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