High Urinary Iodine Concentration Among Breastfed Infants and the Factors Associated with Iodine Content in Breast Milk |
| |
| Authors: | Oraporn Dumrongwongsiri Suthida Chatvutinun Phanphen Phoonlabdacha Areeporn Sangcakul La-or Chailurkit Atitaya Siripinyanond Umaporn Suthutvoravut Nalinee Chongviriyaphan |
| |
| Institution: | 1.Department of Biochemistry, Falavarjan Branch,Islamic Azad University,Isfahan,Iran;2.Department of Biology, Faculty of Basic Sciences,Shahrekord University,Shahrekord,Iran;3.Department of Pathology,Isfahan University of Medical Sciences,Isfahan,Iran;4.Department of Anatomy Sciences,Isfahan University of Medical Scienses,Isfahan,Iran |
| |
| Abstract: | Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rats each. The Cd group was treated with 1 mg Cd/kg and the control group received 0.5 cm3 normal saline. The other eight groups received Zn (0.5 and 1.5 mg/kg) and Mg (0.5 and 1.5 mg/kg) either alone or in combination with 1 mg Cd/kg through IP injection for 3 weeks. Testis malondialdehyde (MDA), sperm parameters, and testis histopathology were investigated. Cd reduced sperm parameters and increased testis MDA. Moreover, Cd exposure caused a significant histological damage in testis of male rats. However, Zn or Mg treatment prevented and reversed Cd toxic alterations in testis. These findings suggest that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
