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Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes. |
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| Authors: | B Andersson D P Jones and S Orrenius |
| Abstract: | The effect of extracellular Ca2+ concentration on ethanol oxidation and drug metabolism was studied in isolated rat hepatocytes. Both ethanol oxidation and drug glucuronidation showed similar dependence upon Ca2+, which was a stimulation of activity as Ca2+ was increased to physiological concentration, and inhibition at higher concentration. |
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