Stable chromosome aberrations 25 years after severe accidental radiation exposure |
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Authors: | A. Maes A. Hilali E. D. Léonard A. Léonard L. Verschaeve |
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Affiliation: | (1) Vlaamse Instelling voor Technologisch Onderzoek (VI.T.O.), Division of Environmental Research, Boeretang 200, B-2400 Mol;(2) Université Catholique de Louvain, Teratogenesis and Mutagenesis Unit, B-1200 Brussels, Belgium |
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Abstract: | A thorough cytogenetic analysis using G-banding was performed on 100 peripheral blood lymphocytes from an individual who had been accidentally exposed to radiation more than 25 years previously. More than 60% of the analysed cells were found to possess one or more stable chromosome aberrations (e.g. reciprocal translocations). Chromosomes 1 and 11 were more involved in these aberrations than would be expected from the relative chromosome lengths. No identical stable aberrations were found, suggesting that, 25 years after nearlethal exposure, haemopoietic stem cells display substantial diversity. |
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