Functional vanilloid receptors in cultured normal human epidermal keratinocytes |
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Authors: | Inoue Kaori Koizumi Schuichi Fuziwara Shigeyoshi Denda Sumiko Inoue Kazuhide Denda Mitsuhiro |
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Affiliation: | Shiseido Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan. kaori.inoue@to.shiseido.co.jp |
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Abstract: | Vanilloid receptor subtype 1, VR1, is an ion channel that serves as a polymodal detector of pain-producing chemicals such as capsaicin and protons in primary afferent neurons. Here we showed that both capsaicin and acidification produced elevations in the intracellular Ca(2+) concentration ([Ca(2+)](i)) in cultured human epidermal keratinocytes. The capsaicin- and acidification-evoked increases in [Ca(2+)](i) were inhibited by capsazepine, an antagonist to VR1. VR1-like immunoreactivity was observed in the cells. These findings suggest that functional VR1-like protein is present and functions as a sensor against noxious chemical stimuli, such as capsaicin or acidification, in epidermal keratinocytes. |
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Keywords: | capsaicin proton VR1 keratinocytes intracellular Ca2+ concentration capsazepine |
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