Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics |
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| Authors: | Kerstin Buttler Taichi Ezaki Jörg Wilting |
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| Institution: | (1) Centre of Anatomy, Department of Anatomy and Cell Biology, University Medicine Goettingen, Goettingen, Germany;(2) Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan;(3) Centre of Anatomy, Department of Anatomy and Cell Biology, University Medicine Goettingen, Kreuzbergring 36, 37075 Goettingen, Germany |
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| Abstract: | Background The data on the embryonic origin of lymphatic endothelial cells (LECs) from either deep embryonic veins or mesenchymal (or
circulating) lymphangioblasts presently available remain inconsistent. In various vertebrates, markers for LECs are first
expressed in specific segments of embryonic veins arguing for a venous origin of lymph vessels. Very recently, studies on
the mouse have strongly supported this view. However, in the chick, we have observed a dual origin of LECs from veins and
from mesodermal lymphangioblasts. Additionally, in murine embryos we have detected mesenchymal cells that co-express LEC markers
and the pan-leukocyte marker CD45. Here, we have characterized the mesoderm of murine embryos with LEC markers Prox1, Lyve-1
and LA102 in combination with macrophage markers CD11b and F4/80. |
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