The effects of neonatal 6-hydroxydopamine induced sympathectomy on response inhibition in extinction. |
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Authors: | E W Thronton A J Goudie V Bithell |
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Affiliation: | Departments of Pharmacology, Physiology and Medicine, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA |
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Abstract: | Superfused helical strips of canine anterior mesenteric arteries and veins and canine dorsal metatarsal veins contract in response to prostaglandin B2 (PGB2). Reserpine pretreatment and phentolamine reduce the constrictor response to PGB2. PGB2 enhances the contractile responses of these preparations to potassium, barium and norepinephrine. PGB2 also produced a shift to the left in the duration of the barium response curve. The data presented demonstrate that PGB2 is not an inactive metabolite of PGA2 metabolism but possesses potent constrictor activity probably dependent on release of norepinephrine from adrenergic nerves. Furthermore, PGB2 enhances the responses of vascular smooth muscle to vasoactive stimuli. |
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Keywords: | Address correspondence to Dr. J.P. Long Department of Pharmacology College of Medicine University of Iowa Iowa City Iowa 52242 USA |
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