Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms |
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| Authors: | Jae-Gyu Jeon Marlise I Klein Jin Xiao Stacy Gregoire Pedro L Rosalen and Hyun Koo |
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| Institution: | (1) Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA;(2) Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA;(3) Department of Preventive Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Republic of Korea;(4) Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), Sao Paulo, Brazil;(5) Natural Product Research in Oral Biology Group (NatPROB), Piracicaba Dental School, University of Campinas (UNICAMP), Sao Paulo, Brazil |
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| Abstract: | Background The association of specific bioactive flavonoids and terpenoids with fluoride can modulate the development of cariogenic biofilms
by simultaneously affecting the synthesis of exopolysaccharides (EPS) and acid production by Streptococcus mutans, which enhanced the cariostatic effectiveness of fluoride in vivo. In the present study, we further investigated whether the biological actions of combinations of myricetin (flavonoid), tt-farnesol (terpenoid) and fluoride can influence the expression of specific genes of S. mutans within biofilms and their structural organization using real-time PCR and confocal fluorescence microscopy. |
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