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Murine interleukin 1 stimulates α2-macroglobulin synthesis in rat hepatocyte primary cultures
Authors:Joachim Bauer  Wolfgang Weber  Thuy-Anh Tran-Thi  Gerd-Hinrich NorthofF  Karl Decker  Wolfgang Gerok  Peter C Heinrich  
Abstract:In rat hepatocyte primary cultures recombinant interleukin 1 was found to stimulate α2-macroglobulin synthesis, whereas albumin synthesis was decreased. Although recent experiments gave evidence that a hepato-cyte-stimulating factor distinct from interleukin 1 must exist, we conclude that interleukin 1 exerts a direct effect on hepatocytes by inducing acute-phase protein synthesis.Interleukin 1α2-MacroglobulinRat hepatocyte
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