Ca2+/phospholipid-dependent protein kinase activity correlates to the ability of transformed liver cells to proliferate in Ca2+-deficient medium |
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| Authors: | A L Boynton J F Whitfield L P Kleine |
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| Institution: | Cell Physiology Group Division of Biological Sciences National Research Council of Canada Ottawa, Canada K1A 0R6 |
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| Abstract: | Extracellular Ca2+-deprivation inhibited the proliferation of normal T51B rat liver cells and reduced (2-4 fold) the amount of EDTA/EGTA-extractable protein kinase C activity. By contrast, preneoplastic and neoplastic T51B rat liver cells were able to proliferate in Ca2+-deficient medium and retained all of their extractable protein kinase C activity. |
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