Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives |
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| Authors: | Naidu B Narasimhulu Sorenson Margaret E Hudyma Thomas Zheng Xiaofan Zhang Yunhui Bronson Joanne J Pucci Michael J Clark Junius M Ueda Yasutsugu |
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| Institution: | The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. narasimhulu.naidu@bms.com |
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| Abstract: | The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1-12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7-9 also exhibited potent in vivo activity. |
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