Translocation of Insulin-Regulated Glucose Transporter Is Stimulated by Long-Chain 1,2-Diacylglycerol in Rat Adipocytes |
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Authors: | Johanna Gustavsson Santiago Parpal Peter Strlfors |
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Institution: | Johanna Gustavsson, Santiago Parpal,Peter Strålfors |
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Abstract: | The long-chain diacylglycerol 1,2-dimyristoylglycerol emulsified with taurodeoxycholate has been shown to potently stimulate glucose transport in isolated rat adipocytes (Strålfors, Nature 335, 554-556 (1988)). We now report that this 1,2-diacylglycerol in the presence of taurodeoxycholate, similarly to insulin, induced translocation of the insulin-regulated glucose transporter (GLUT-4) from a microsomal membrane compartment to the plasma membrane. H4IIE hepatoma cells expressed mRNA for GLUT-1, but not for GLUT-4. In these, otherwise insulin-responsive, cells diacylglycerol or insulin had only a marginal effect on glucose transport. |
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