Effect of pefloxacin on immune response] |
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| Authors: | N G Artsimovich N N Nastoiashchaia P S Navashin |
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| Affiliation: | Institute of Immunology, Ministry of Health of Russian Federation, Moscow. |
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| Abstract: | The influence on cellular immune response of different doses of the pefloxacin was studied in vivo as well as in vitro experiments. The pefloxacin in super bactericidal concentrations (2.0 mg/ml and 0.4 mg/ml) possess pronounced supressing effect the T-lymphocyte proliferation in blast transformation reaction. While in concentration 0.08 mg/ml pefloxacin does not show such activity. The pefloxacin in maximal effective concentration (200 mg/kg) suppressed activity in delayed hypersensitivity skin reaction of intact mice towards sheep erythrocytes on 20.3 percent only. |
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