High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone |
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| Authors: | Yoshifumi S Hirokawa Akimitsu Takagi Katsunori Uchida Yuji Kozuka Misao Yoneda Masatoshi Watanabe Taizo Shiraishi |
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| Institution: | (1) Department of Pathological Oncology, Institute of Molecular and Experimental Medicine, Faculty of Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan;(2) Laboratory for Medical Engineering, Division of Materials Science and Chemical Engineering, Graduate School of Engineering, Yokohama National University, Yokohama, Japan |
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| Abstract: | In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial
phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically
faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8
and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1. |
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| Keywords: | STAG1/PMEPA1 IL-8 E-cadherin Prostate cancer cell line |
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