The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families |
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Authors: | Riccardo Percudani and Alessio Peracchi |
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Affiliation: | (1) Department of Biochemistry and Molecular Biology, University of Parma, 43100 Parma, Italy |
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Abstract: | Background - Enzymes that depend on vitamin B6 (and in particular on its metabolically active form, pyridoxal 5'-phosphate, PLP) are of great relevance to biology and medicine, as they catalyze a wide variety of biochemical reactions mainly involving amino acid substrates. Although PLP-dependent enzymes belong to a small number of independent evolutionary lineages, they encompass more than 160 distinct catalytic functions, thus representing a striking example of divergent evolution. The importance and remarkable versatility of these enzymes, as well as the difficulties in their functional classification, create a need for an integrated source of information about them. |
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