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Integrated dataset of screening hits against multiple neglected disease pathogens |
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| Authors: | Nwaka Solomon Besson Dominique Ramirez Bernadette Maes Louis Matheeussen An Bickle Quentin Mansour Nuha R Yousif Fouad Townson Simon Gokool Suzanne Cho-Ngwa Fidelis Samje Moses Misra-Bhattacharya Shailja Murthy P K Fakorede Foluke Paris Jean-Marc Yeates Clive Ridley Robert Van Voorhis Wesley C Geary Timothy |
| Institution: | Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland. nwakas@who.int |
| Abstract: | New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach. |
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