Evolution and Diversification of RNA Silencing Proteins in Fungi |
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Authors: | Hitoshi Nakayashiki Naoki Kadotani Shigeyuki Mayama |
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Institution: | (1) Laboratory of Plant Pathology, Kobe University, 1-1 Rokkodai-cho, Nada-ku Kobe, 657-8501, Japan |
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Abstract: | Comprehensive phylogenetic analyses of fungal Argonaute, Dicer, and RNA-dependent RNA polymerase-like proteins have been performed
to gain insights into the diversification of RNA silencing pathways during the evolution of fungi. A wide range of fungi including
ascomycetes, basidiomycetyes, and zygomycetes possesses multiple RNA silencing components in the genome, whereas a portion
of ascomycete and basidiomycete fungi apparently lacks the whole or most of the components. The number of paralogous silencing
proteins in the genome differs considerably among fungal species, suggesting that RNA silencing pathways have diversified
significantly during evolution in parallel with developing the complexity of life cycle or in response to environmental conditions.
Interestingly, orthologous silencing proteins from different fungal clades are often clustered more closely than paralogous
proteins in a fungus, indicating that duplication events occurred before speciation events. Therefore, the origin of multiple
RNA silencing pathways seems to be very ancient, likely having occurred prior to the divergence of the major fungal lineages.
Electronic Supplementary Material Electronic Supplementary material is available for this article at
and accessible for authorised users.
Reviewing Editor: Dr. Rüdiger Cerff] |
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Keywords: | RNA silencing RNA interference (RNAi) Dicer Argonaute RNA-dependent RNA polymerase Fungi |
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