Heterogeneity of the memory CD4 T cell response: persisting effectors and resting memory T cells |
| |
Authors: | Ahmadzadeh M Hussain S F Farber D L |
| |
Institution: | Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. |
| |
Abstract: | Defining the cellular composition of the memory T cell pool has been complicated by an inability to distinguish effector and memory T cells. We present here an activation profile assay, using anti-CD3 and antigenic stimuli, that clearly distinguishes effector and memory CD4 T cells and defines subsets of long-lived memory CD4 T cells based on CD62 ligand (CD62L) expression. The CD62L(low) memory subset functionally resembles effector cells, exhibiting hyper-responsiveness to antigenic and anti-CD3 mediated stimuli, high proliferative capacity, and rapid activation kinetics. The CD62L(high) memory subset functionally resembles resting memory cells, exhibiting hyporesponsiveness to anti-CD3 stimuli, lower proliferative capacity, and slower activation kinetics. Our results indicate that the memory CD4 T cell pool is heterogeneous, consisting of persisting effectors and resting memory T cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|