| 中药降乳散对大鼠催乳素瘤表达Pit-1的作用 |
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| 引用本文： | 张韶峰,邱文娟,徐春.中药降乳散对大鼠催乳素瘤表达Pit-1的作用[J].中国实验动物学报,2008,16(6):455-457. |
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| 作者姓名： | 张韶峰 邱文娟 徐春 |
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| 作者单位： | 武警总医院,北京,100039 |
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| 基金项目： | 首都医学发展科研基金(中医药类)
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武警总医院科研项目
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| 摘 要： | 目的研究中药降乳散对大鼠催乳素（PRL）瘤组织表达Pit-1的作用。方法用皮下植入雌激素的方法制备大鼠PRL瘤模型,将成功诱发出PRL瘤的大鼠随机分2组,分别给予安慰剂和中药降乳散灌胃,用药4周后处死动物,垂体称重,用放免法测定血清PRL水平。用反转录-PCR方法分析Pit-1在大鼠PRL瘤组织中的表达量。结果降乳散组大鼠血清PRL水平和垂体重量均明显低于安慰剂组（P〈0.001）,Pit-1 mRNA水平在降乳散组较安慰剂组明显降低（P〈0.001）。结论降低Pit-1的表达水平可能是中药降乳散抗PRL瘤的重要机制之一。
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| 关 键 词： | 雌激素 催乳素瘤 大鼠 Pit-1 中药 |
Effect of the Chinese Medicine,Jiangrusan,on the Expression of Pit-1 in Rat Prolactinoma |
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| ZHANG Shao-feng,QIU Wen-juan,XU Chun.Effect of the Chinese Medicine,Jiangrusan,on the Expression of Pit-1 in Rat Prolactinoma[J].Acta Laboratorium Animalis Scientia Sinica,2008,16(6):455-457. |
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| Authors: | ZHANG Shao-feng QIU Wen-juan XU Chun |
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| Institution: | ZHANG Shao-feng,QIU Wen-juan,XU Chun(The General Hospital of Chinese People\'s Armed Police Forces,Beijing 100039,China) |
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| Abstract: | Objective To study the effect of the Chinese medicine,Jiangrusan,on the expression of Pit-1 in rat prolactinoma.Methods\ To establish prolactinoma model in rats.The Prolactinoma-bearing rats were divided into 2 groups at random.Jiangrusan was orally administered to rats in the Jiangrusan group,and water was administered to rats in the placebo group.After 4 weeks of treatment,all animals were sacrificed and the pituitary gland was taken out and weighed.Serum prolactin(PRL) levels were measured by RIA method.... |
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| Keywords: | Pit-1 |
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