Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors |
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Authors: | Isia Bursuker Robert J. North |
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Affiliation: | (1) Trudeau Institute, Inc., P.O. Box 59, 12983 Saranac Lake, NY, USA;(2) Immunology Department, Bristol-Myers Co., Bldg. 32A, PR & DD, P.O. Box 4755, 13221 Syracuse, N.Y., USA |
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Abstract: | Summary Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.This work was supported by Grants CA-16642 and CA-17794 from the National Cancer Institute, Grant RR-05705 from the Division of Research Resources, NIH, and a grant from R. J. Reynolds Industries, Inc |
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