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Effect of 3D-scaffold formation on differentiation and survival in human neural progenitor cells |
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| Authors: | Stefanie Ortinau Jürgen Schmich Stephan Block Andrea Liedmann Ludwig Jonas Dieter G Weiss Christiane A Helm Arndt Rolfs Moritz J Frech |
| Institution: | 1.Albrecht-Kossel-Institute for Neuroregeneration,University of Rostock,Rostock,Germany;2.Institute for Physics,Ernst-Moritz-Arndt University Greifswald,Greifswald,Germany;3.Electron Microscopic Centre, Institute of Pathology,University of Rostock,Rostock,Germany;4.Division of Cell Biology and Biosystems Technology, Institute of Biological Sciences,University of Rostock,Rostock,Germany |
| Abstract: | Background3D-scaffolds have been shown to direct cell growth and differentiation in many different cell types, with the formation and functionalisation of the 3D-microenvironment being important in determining the fate of the embedded cells. Here we used a hydrogel-based scaffold to investigate the influences of matrix concentration and functionalisation with laminin on the formation of the scaffolds, and the effect of these scaffolds on human neural progenitor cells cultured within them. |
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