The study of structure-antiarrhythmic activity relationship of N-phenylacetamide derivatives and aromatic carbonic acid amides |
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| Authors: | V. R. Khairullina G. P. Tarasov A. Ya. Gerchikov F. S. Zarydiy L. A. Tyurina |
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| Affiliation: | 1.Bashkir State University,Ufa, Bashkortostan,Russia;2.Institute of Organic Chemistry,Ufa Scientific Center of Russian Academy of Sciences,Ufa, Bashkortostan,Russia |
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| Abstract: | Using the SARD-21 (Structure Activity Relationship & Design) computer system, structural features of high- and low-effective antiarrhythmic agents have been recognized and the influence of these features on the antiarrhythmic properties has been evaluated. This information has been used for generation of the model to predict antiarrhythmic effectiveness of pharmaceutical preparations at the recognition level of 82% by means of two different approaches. The recognized structural parameters may be successfully used to design new highly effective antiarrhythmic drugs, and also to modify structures of the already-existing anti-arrhythmic drugs in order to increase the effectiveness of their antiarrhythmic action. |
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