Quantitative Trait Loci (QTL) Associated with Resistance to a Monogenean Parasite (Benedenia seriolae) in Yellowtail (Seriola quinqueradiata) through Genome Wide Analysis |
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| Authors: | Akiyuki Ozaki Kazunori Yoshida Kanako Fuji Satoshi Kubota Wataru Kai Jun-ya Aoki Yumi Kawabata Junpei Suzuki Kazuki Akita Takashi Koyama Masahiro Nakagawa Takurou Hotta Tatsuo Tsuzaki Nobuaki Okamoto Kazuo Araki Takashi Sakamoto |
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| Institution: | 1. National Research Institute of Aquaculture, Fisheries Research Agency, Nakatsuhamaura, Minamiise-cho, Watarai-gun, Mie, Japan.; 2. Seikai National Fisheries Research Institute, Fisheries Research Agency, Nunoura, Tamanoura-machi, Goto-shi, Nagasaki, Japan.; 3. Faculty of Marine Science, Tokyo University of Marine Science and Technology, Konan, Minato-ku, Tokyo, Japan.; Pennsylvania State University, United States of America, |
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| Abstract: | Benedenia infections caused by the monogenean fluke ectoparasite Benedenia seriolae seriously impact marine finfish aquaculture. Genetic variation has been inferred to play a significant role in determining the susceptibility to this parasitic disease. To evaluate the genetic basis of Benedenia disease resistance in yellowtail (Seriola quinqueradiata), a genome-wide and chromosome-wide linkage analyses were initiated using F1 yellowtail families (n = 90 per family) based on a high-density linkage map with 860 microsatellite and 142 single nucleotide polymorphism (SNP) markers. Two major quantitative trait loci (QTL) regions on linkage groups Squ2 (BDR-1) and Squ20 (BDR-2) were identified. These QTL regions explained 32.9–35.5% of the phenotypic variance. On the other hand, we investigated the relationship between QTL for susceptibility to B. seriolae and QTL for fish body size. The QTL related to growth was found on another linkage group (Squ7). As a result, this is the first genetic evidence that contributes to detailing phenotypic resistance to Benedenia disease, and the results will help resolve the mechanism of resistance to this important parasitic infection of yellowtail. |
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