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Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
Affiliation:1. Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA;2. Department of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;3. Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;4. Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China
Abstract:
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  • Keywords:replication stress  fork resection  TRPV2  cytosolic DNA  cGAS  STING  TREX1  CaMKK2  AMPK
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