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Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control
Affiliation:1. Department of Hematology/Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;2. Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Abstract:
Keywords:DNA-damage repair  mismatch repair deficits  PARP  ATR  immuno-oncology  immune checkpoint blockade  biomarkers  STING  cGAS-STING  DDRi-IO  cellular therapy
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