Interaction of active compounds from Aegle marmelos CORREA with histamine-1 receptor

The aim of this study is to determine the affinity of six active compounds of Aegle Marmelos Correa, they are (E, R)-Marmin,skimmianine, (S)-aegeline, aurapten, zeorin, and dustanin as antihistamines in histamine H1 receptor in comparison to cetirizin,diphenhydramine and chlorpheniramine as ligands comparison. Previously, in the in vitro study marmin obviously antagonizedthe histamine H1 receptor in a competitive manner. Methods: molecular docking to determine the interaction of ligand binding to itsreceptor. Lower docking score indicates more stable binding to that protein. Results: Marmin, skimmianine, aegeline, aurapten,zeorin, and dustanin were potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists byinteracting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor. Conclusions: Based onmolecular docking, Amino acid residues involved in ligand protein interactions were Asp107, Lys179, Lys191, Asn198, and Trp428.