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CRISPR-free,programmable RNA pseudouridylation to suppress premature termination codons
Affiliation:1. State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, PRC;2. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, PRC;3. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, PRC;4. College of Chemistry and Molecular Engineering, Peking University, Beijing, PRC;5. Elpis Biotechnology Company Limited, Beijing, PRC;6. Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, PRC;7. Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital of Fudan University, Shanghai, PRC;8. Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, PRC
Abstract:
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  • Keywords:RNA base editor  pseudourine  snoRNA  DKC1  nonsense mutation  PTC readthrough  RNA editing  RNA modification  premature termination codon  RNA targeting
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