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Ring domains are essential for GATOR2-dependent mTORC1 activation
Affiliation:1. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA;2. Joint Research Center for Musculoskeletal Tumor of Shanghai Changzheng Hospital and University of Shanghai for Science and Technology, Spinal Tumor Center, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Shanghai 200003, China;3. Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200092, China;4. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;5. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China;6. Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA
Abstract:
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  • Keywords:Gator2  WDR24  Gator1  amino acid sensing  ubiquitination  NPRL2  Sestrin  mTOR
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